Unusual Reaction to Chlorpromazine

Prolonged dystonic reaction to chlorpromazine in myxoedema coma.

A case of myxoedema coma is reported where the administration of chlorpromazine resulted in a prolonged dystonic reaction. A similar challenge with a butyrophenone when the patient was on thyroxine caused a similar but much abbreviated response.

An unusual reaction to rabies vaccine.

This report describes a previously undescribed reaction to human diploid cell rabies vaccine (HDCV). The vaccine is available for prophylaxis against Australian bat lyssavirus (ABL) infection both prior to and after possible exposure. Australian bat lyssavirus is the most recent lyssavirus to be discovered and has been linked to at least one death in Queensland. HDCV appears to be effective aga...

An unusual adverse drug reaction?

INTRODUCTION Adult Still Disease (ASD) is a rare (incidence 1-1,6/1,000,000 in Europe) seronegative polyarthropathy diagnosed with clinical criteria, excluding other etiologies. Minocycline, a semisynthetic derivative of tetracycline, has been associated with many adverse effects. We present the case of a 18-years-old man with a high suspicion of an adverse drug reaction (ADR), that was finally...

An unusual Jarisch-Herxheimer reaction.

Unusual skin reaction to silicone content in breast implants.

We present a patient who had a long history of unsuccessful bilateral mammary operations with insertion and extraction of various implants, some of which were filled with silicone gel, others with saline. In addition to complications in the tissue surrounding the prosthesis, she had distant widespread skin lesions which, we believe, were due to leakage from the implant. A cutaneous test with ma...